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Anisotropic analysis of multi-component T2 and T1? relaxations in achilles tendon by NMR spectroscopy and microscopic MRI.


ABSTRACT: To study the anisotropic characteristics of both multi-component T2 and T1? relaxation times in tendon.T2 and T1? were measured in tendon by NMR spectroscopy at different orientations and by microscopic MRI at the magic angle. Several experimental issues in the multi-component relaxation measurements were investigated, including the effects of echo spacing, the resolution of MRI experiments, the influence of the specimen orientations, and the strengths of different spin-lock frequencies in T1? experiments.Both the values and fractions of T2 in tendon showed significant orientational dependence. The values and fractions of T1? strongly depended on both the specimen orientation and the spin-lock strength. The imaging resolution (35-280 ?m) had little influence in the T2 experiments. Both the echo spacings (0.6-3.0 ms) in the T2 experiment and the spin-lock strengths (0.5-5 kHz) in the T1? experiment affected the quantification of the multi-component relaxation. Up to three T2 and T1? components were resolved in tendon.Multi-component relaxations could be attributed to different populations of water in the tissue. The transitions between a mono-component and multi-component result call for the caution in interpreting the relaxation results.

SUBMITTER: Wang N 

PROVIDER: S-EPMC3638061 | BioStudies | 2013-01-01

REPOSITORIES: biostudies

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