Unknown

Dataset Information

0

PurBayes: estimating tumor cellularity and subclonality in next-generation sequencing data.


ABSTRACT:

Summary

We have developed a novel Bayesian method, PurBayes, to estimate tumor purity and detect intratumor heterogeneity based on next-generation sequencing data of paired tumor-normal tissue samples, which uses finite mixture modeling methods. We demonstrate our approach using simulated data and discuss its performance under varying conditions.

Availability

PurBayes is implemented as an R package, and source code is available for download through CRAN at http://cran.r-project.org/package=PurBayes.

Contact

larson.nicholas@mayo.edu

Supplementary information

Supplementary data are available online at Bioinformatics online.

SUBMITTER: Larson NB 

PROVIDER: S-EPMC3712213 | BioStudies | 2013-01-01

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5860163 | BioStudies
2016-01-01 | S-EPMC5079475 | BioStudies
1000-01-01 | S-EPMC5408773 | BioStudies
1000-01-01 | S-EPMC4817050 | BioStudies
1000-01-01 | S-EPMC3198581 | BioStudies
2019-01-01 | S-EPMC6341661 | BioStudies
2019-01-01 | S-EPMC6761978 | BioStudies
2018-01-01 | S-EPMC5925766 | BioStudies
1000-01-01 | S-EPMC4287944 | BioStudies
2019-01-01 | S-EPMC6853702 | BioStudies