Unknown

Dataset Information

0

PLZF mediates the PTEN/AKT/FOXO3a signaling in suppression of prostate tumorigenesis.


ABSTRACT: Promyelocytic leukemia zinc finger (PLZF) protein expression is closely related to the progression of human cancers, including prostate cancer (PCa). However, the according context of a signaling pathway for PLZF to suppress prostate tumorigenesis remains greatly unknown. Here we report that PLZF is a downstream mediator of the PTEN signaling pathway in PCa. We found that PLZF expression is closely correlated with PTEN expression in a cohort of prostate cancer specimens. Interestingly, both PTEN rescue and phosphoinositide 3-kinase (PI3K) inhibitor LY294002 treatment increase the PLZF expression in prostate cancer cell lines. Further, luciferase reporter assay and chromatin immunoprecipitation assay demonstrate that FOXO3a, a transcriptional factor phosphorylated by PI3K/AKT, could directly bind to the promoter of PLZF gene. These results indicate that PTEN regulates PLZF expression by AKT/FOXO3a. Moreover, our animal experiments also demonstrate that PLZF is capable of inhibiting prostate tumorigenesis in vivo. Taken together, our study defines a PTEN/PLZF pathway and would shed new lights for developing therapeutic strategy of prostate cancer.

SUBMITTER: Cao J 

PROVIDER: S-EPMC3858220 | BioStudies | 2013-01-01

REPOSITORIES: biostudies

Similar Datasets

2019-01-01 | S-EPMC6532645 | BioStudies
2015-01-01 | S-EPMC4373907 | BioStudies
2019-01-01 | S-EPMC6404554 | BioStudies
2015-01-01 | S-EPMC4517568 | BioStudies
1000-01-01 | S-EPMC5356562 | BioStudies
1000-01-01 | S-EPMC3710885 | BioStudies
2020-01-01 | S-EPMC7281005 | BioStudies
2019-01-01 | S-EPMC6760172 | BioStudies
2015-01-01 | S-EPMC4433564 | BioStudies
2019-01-01 | S-EPMC6587168 | BioStudies