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Vitamin E, ?-tocopherol, diminishes ex vivo basophil response to dust mite allergen.


ABSTRACT: Epidemiologic studies suggest that dietary vitamin E is a candidate intervention for atopic disease. We used in vitro and ex vivo exposures to test the hypothesis that the most common dietary isoform of vitamin E, ?-tocopherol (?T), could suppress Fc?RI-mediated basophil activation. Rat basophilic leukemia (RBL)-SX38 cells that express human Fc?RI were treated with or without ?T, followed by stimulation with ?-IgE. In the ex vivo study, 20 Der f 1-allergic volunteers consumed a ?T-enriched supplement for 7 days. Their basophils were challenged ex vivo with ?-IgE and graded doses of Der f 1 before and after the supplementation period. ?t treatment of RBL-SX38 cells significantly reduced basophil degranulation and de novo TH2 cytokine production. Daily consumption of a ?T-rich supplement by dust mite-allergic volunteers reduced basophil activation after ex vivo dust mite challenge. Vitamin E supplements rich in ?T may be useful adjuncts in decreasing atopic disease.

SUBMITTER: Mills K 

PROVIDER: S-EPMC3989399 | BioStudies | 2014-01-01

REPOSITORIES: biostudies

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