Unknown

Dataset Information

0

Iron-catalysed, general and operationally simple formal hydrogenation using Fe(OTf)3 and NaBH4.


ABSTRACT: An operationally simple and environmentally benign formal hydrogenation protocol has been developed using highly abundant iron(iii) salts and an inexpensive, bench stable, stoichiometric reductant, NaBH4, in ethanol, under ambient conditions. This reaction has been applied to the reduction of terminal alkenes (22 examples, up to 95% yield) and nitro-groups (26 examples, up to 95% yield). Deuterium labelling studies indicate that this reaction proceeds via an ionic rather than radical mechanism.

SUBMITTER: MacNair AJ 

PROVIDER: S-EPMC4295815 | BioStudies | 2014-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2013-01-01 | S-EPMC6269978 | BioStudies
2017-01-01 | S-EPMC5732263 | BioStudies
2012-01-09 | E-GEOD-26627 | ArrayExpress
1000-01-01 | S-EPMC4531819 | BioStudies
2015-01-01 | S-EPMC4533119 | BioStudies
2012-01-01 | S-EPMC3312506 | BioStudies
2020-01-01 | S-EPMC7182861 | BioStudies
2020-01-01 | S-EPMC7331048 | BioStudies
1000-01-01 | S-EPMC6207922 | BioStudies
2007-01-01 | S-EPMC2519602 | BioStudies