Dataset Information


Automatic Generation of Validated Specific Epitope Sets.

ABSTRACT: Accurate measurement of B and T cell responses is a valuable tool to study autoimmunity, allergies, immunity to pathogens, and host-pathogen interactions and assist in the design and evaluation of T cell vaccines and immunotherapies. In this context, it is desirable to elucidate a method to select validated reference sets of epitopes to allow detection of T and B cells. However, the ever-growing information contained in the Immune Epitope Database (IEDB) and the differences in quality and subjects studied between epitope assays make this task complicated. In this study, we develop a novel method to automatically select reference epitope sets according to a categorization system employed by the IEDB. From the sets generated, three epitope sets (EBV, mycobacteria and dengue) were experimentally validated by detection of T cell reactivity ex vivo from human donors. Furthermore, a web application that will potentially be implemented in the IEDB was created to allow users the capacity to generate customized epitope sets.

SUBMITTER: Carrasco Pro S 

PROVIDER: S-EPMC4629045 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

Similar Datasets

2017-01-01 | S-EPMC5348633 | BioStudies
2020-01-01 | S-EPMC7792572 | BioStudies
2011-01-01 | S-EPMC3124689 | BioStudies
2020-01-01 | S-EPMC7106935 | BioStudies
2011-01-01 | S-EPMC3013771 | BioStudies
2020-01-01 | S-EPMC6970984 | BioStudies
2007-01-01 | S-EPMC1765443 | BioStudies
2015-01-01 | S-EPMC4447415 | BioStudies
2009-01-01 | S-EPMC2747625 | BioStudies
2019-01-01 | S-EPMC6602498 | BioStudies