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Nfkb1 suppresses DNA alkylation-induced tumor formation.


ABSTRACT: NF-κB proteins play a complex role in modulating carcinogenesis following DNA damage. Previous work identified p50/NF-κB1 as a necessary factor in the cytotoxic response to alkylation damage. Recently, these findings were extended to demonstrate that in the setting of alkylation damage, this NF-κB subunit acts as a haploinsufficient tumor suppressor that prevents hematologic malignancy formation.

PROVIDER: S-EPMC4905238 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

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