Dataset Information


IL-17 Promotes Angiogenic Factors IL-6, IL-8, and Vegf Production via Stat1 in Lung Adenocarcinoma.

ABSTRACT: Inflammation and angiogenesis are two hallmarks of carcinoma. The proinflammatory cytokine interleukin-17 (IL-17) facilitates angiogenesis in lung cancer; however, the underlying mechanism is not fully understood. In this study, tumour microvessel density (MVD) was positively associated with IL-17, interleukin-6 (IL-6), interleukin-8 (IL-8), and vascular endothelial cell growth factor (VEGF) expression in human lung adenocarcinoma tissues, and it was increased in tumour tissues of A549-IL-17 cell-bearing nude mice. Importantly, positive correlations were also detected between IL-17 expression and IL-6, IL-8 and VEGF expression in human lung adenocarcinoma tissues. Furthermore, IL-6, IL-8 and VEGF production, as well as STAT1 phosphorylation, were increased in tumour tissues of A549-IL-17 cell-bearing nude mice in vivo and in A549 and H292 cells following IL-17 stimulation in vitro. In addition, STAT1 knockdown using an inhibitor and siRNA attenuated the IL-17-mediated increases in IL-6, IL-8 and VEGF expression in A549 and H292 cells. In conclusion, IL-17 may promote the production of the angiogenic inducers IL-6, IL-8 and VEGF via STAT1 signalling in lung adenocarcinoma.


PROVIDER: S-EPMC5098156 | BioStudies | 2016-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC4261178 | BioStudies
2019-01-01 | S-EPMC6601590 | BioStudies
1998-01-01 | S-EPMC1219157 | BioStudies
2013-01-01 | S-EPMC3906956 | BioStudies
2019-01-01 | S-EPMC6717735 | BioStudies
1000-01-01 | S-EPMC5674966 | BioStudies
2011-01-01 | S-EPMC3118969 | BioStudies
2011-01-01 | S-EPMC3149226 | BioStudies
1000-01-01 | S-EPMC3786637 | BioStudies
2008-01-01 | S-EPMC2516523 | BioStudies