Unknown

Dataset Information

0

Visualization by live-cell microscopy of disruption of ND10 during herpes simplex virus type 1 infection.


ABSTRACT: ND10 structures are disrupted during herpes simplex virus type 1 (HSV-1) infection by viral regulatory protein ICP0. The significance of this effect remains controversial, partly because of a report that high-level expression of the major ND10 promyelocytic leukemia (PML) protein precludes ND10 disruption yet does not inhibit HSV-1 infection. Here we demonstrate dramatic reorganization of ND10 during HSV-1 infection by live-cell microscopy, even in the presence of overexpressed PML.

SUBMITTER: Everett RD 

PROVIDER: S-EPMC521835 | BioStudies | 2004-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

2015-01-01 | S-EPMC4442361 | BioStudies
2010-01-01 | S-EPMC2849514 | BioStudies
2011-01-01 | S-EPMC3136452 | BioStudies
2011-01-01 | S-EPMC3147933 | BioStudies
1000-01-01 | S-EPMC1069553 | BioStudies
1000-01-01 | S-EPMC3554063 | BioStudies
1000-01-01 | S-EPMC5923075 | BioStudies
2017-01-01 | S-EPMC5441741 | BioStudies
2003-01-01 | S-EPMC167235 | BioStudies
2011-01-01 | S-EPMC3010193 | BioStudies