Unknown

Dataset Information

0

Serum ?2-microglobulin is frequently elevated in type 1 Gaucher patients.


ABSTRACT: ?2-Microglobulin is the major prognostic factor in multiple myeloma, a known comorbidity of Gaucher disease. We evaluated herein serum ?2-microglobulin levels of 31 type 1 Gaucher patients; for 8/31 patients, pre- and post-treatment comparisons were made. Thirteen patients (on treatment = 6) had high levels of ?2-microglobulin, and showed higher chitotriosidase activity and Severity Score Index, and lower concentration of platelets, than patients with normal levels. Levels of ?2-microglobulin correlated with chitotriosidase activity (? = 0.65; p < 0.01), platelets (? = - 0.42; p = 0.02) and ?1- (? = 0.43; p = 0.02) and ?2-protein bands (? = - 0.40; p = 0.03). Regarding pre- and post-treatment values, median ?2-microglobulin levels decreased after treatment (pre- = 2931 ng/mL; post- = 1970 ng/mL; p < 0.01). Our data suggest that levels of serum ?2-microglobulin are frequently elevated in type 1 Gaucher patients, correlate with severity of the disease and decrease after treatment.

SUBMITTER: Koppe T 

PROVIDER: S-EPMC5471151 | BioStudies | 2015-01-01

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC4094900 | BioStudies
2019-01-01 | S-EPMC6838951 | BioStudies
2012-01-01 | S-EPMC3590092 | BioStudies
2016-01-01 | S-EPMC5011488 | BioStudies
2011-01-01 | S-EPMC3186206 | BioStudies
2018-01-01 | S-EPMC6167838 | BioStudies
2021-01-01 | S-EPMC7849573 | BioStudies
2016-01-01 | S-EPMC5234703 | BioStudies
2012-01-01 | S-EPMC3286762 | BioStudies
2017-01-01 | S-EPMC5248516 | BioStudies