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Palladium-Catalyzed ?-Arylation of ?-Keto Esters.


ABSTRACT: A catalyst system derived from commercially available Pd2(dba)3 and PtBu3 has been applied to the coupling of ?-keto ester enolates and aryl bromides. The reaction provides access to an array of ?-stereogenic ?-keto esters. When the air-stable ligand precursor PtBu3·HBF4 is employed, the reaction can be carried out without use of a glovebox. The derived products are of broad interest given the prevalence of the ?-keto acid substructure in biologically important molecules.

SUBMITTER: Zavesky BP 

PROVIDER: S-EPMC5598777 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

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