Unknown

Dataset Information

0

High number of chromosomal copy number aberrations inversely relates to t(11;19)(q21;p13) translocation status in mucoepidermoid carcinoma of the salivary glands.


ABSTRACT: Although rare, mucoepidermoid carcinoma (MEC) is one of the most common malignant salivary gland tumors. The presence of the t(11;19)(q21;p13) translocation in a subset of MECs has raised interest in genomic aberrations in MEC. In the present study we conducted genome-wide copy-number-aberration analysis by micro-array comparative-genomic-hybridization on 27 MEC samples. Low/intermediate-grade MECs had significantly fewer copy-number-aberrations compared to high-grade MECs (low vs high: 3.48 vs 30; p = 0.0025; intermediate vs high: 5.7 vs 34.5; p = 0.036). The translocation-negative MECs contained more copy-number-aberrations than translocation-positive MECs (average amount of aberrations 15.9 vs 2.41; p =0.04). Within all 27 MEC samples, 16p11.2 and several regions on 8q were the most frequently gained regions , while 1q23.3 was the most frequently detected loss. Low/intermediate-grade MEC samples had copy-number-aberrations in chromosomes 1, 12 and 16, while high-grade MECs had a copy-number-aberration in 8p. The most commonly observed copy-number-aberration was the deletion of 3p14.1, which was observed in 4 of the translocation-negative MEC samples. No recurrent copy-number-aberrations were found in translocation-positive MEC samples. Based on these results, we conclude that MECs may be classified as follows: (i) t(11;19)(q21;p13) translocation-positive tumors with no or few chromosomal aberrations and (ii) translocation-negative tumors with multiple chromosomal aberrations.

SUBMITTER: Matse JH 

PROVIDER: S-EPMC5642491 | BioStudies | 2017-01-01

REPOSITORIES: biostudies

Similar Datasets

2017-11-01 | GSE87353 | GEO
2017-01-01 | S-EPMC5182193 | BioStudies
2013-01-01 | S-EPMC3668022 | BioStudies
2019-01-01 | S-EPMC6629427 | BioStudies
2017-01-01 | S-EPMC5433350 | BioStudies
2018-01-01 | S-EPMC5889358 | BioStudies
2018-01-01 | S-EPMC6130818 | BioStudies
1000-01-01 | S-EPMC6115606 | BioStudies
2015-01-01 | S-EPMC4482394 | BioStudies
2010-03-09 | GSE15172 | GEO