Unknown

Dataset Information

0

Early Cervical Cancer: Predictive Relevance of Preoperative 3-Tesla Multiparametric Magnetic Resonance Imaging.


ABSTRACT: Objective:We assess the predictive significance of preoperative 3-Tesla multiparametric MRI findings. Methods:A total of 260 patients with FIGO IA2-IIA cervical cancer underwent primary surgical treatment between 2007 and 2016. Univariable and multivariable logistic regression analyses were used to assess the incremental prognostic significance. Results:The clinical predictive factors associated with pT2b disease were MRI parametrial invasion (PMI) (adjusted odds ratio (AOR) 3.77, 95% confidence interval(CI) 1.62-8.79; P=0.02) and MRI uterine corpus invasion (UCI) (AOR 9.99, 95% CI 4.11-24.32; P<0.0001). In multivariable analysis, for underdiagnoses, histologically squamous carcinoma versus adenocarcinoma and adenosquamous carcinoma (AOR 2.07, 95% CI 1.06-4.07; P=0.034) and MRI tumor size (AOR 0.76, 95% CI 0.63-0.92; P=0.005) were significant predictors; for overdiagnoses, these results were MRI tumor size (AOR 1.51, 95% CI 1.06-2.16; P=0.023), MRI PMI (AOR 71.73, 95% CI 8.89-611.38; P<0.0001) and MRI UCI (AOR 0.19, 95% CI 0.01-1.01; P=0.051). Conclusion:PMI and UCI on T2-weighted images through preoperative 3T MRI are useful coefficients for accurate prediction of the pT2b stage; however, careful surveillance is required. Therefore, preoperative decision-making for early cervical cancer patients based on MRI diagnosis should be considered carefully, particularly in the presence of factors that are known to increase the likelihood of misdiagnosis.

SUBMITTER: Roh HJ 

PROVIDER: S-EPMC6092969 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

Similar Datasets

2018-01-01 | S-EPMC6233789 | BioStudies
2020-01-01 | S-EPMC6918891 | BioStudies
2012-01-01 | S-EPMC3682834 | BioStudies
2014-01-01 | S-EPMC4167873 | BioStudies
2019-01-01 | S-EPMC6775657 | BioStudies
2019-01-01 | S-EPMC6536360 | BioStudies
2020-01-01 | S-EPMC7065827 | BioStudies
2013-01-01 | S-EPMC3557554 | BioStudies
2019-01-01 | S-EPMC6547245 | BioStudies
2007-01-01 | S-EPMC3000829 | BioStudies