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Estrogen receptor ? is associated with expression of cancer associated genes and survival in ovarian cancer.


ABSTRACT: BACKGROUND:In ovarian cancer, the role of estrogen receptors (ERs), particularly of ER?, being suggested as tumor suppressor in breast and prostate cancer, remains unclear. We examined the expression of nuclear and cytoplasmic ER? in ovarian cancer and correlated it with expression of ovarian cancer markers CA125, CEA and CA72-4, steroid hormone receptors ER? and PR, cancer-associated genes EGFR, p53, HER2 and proliferation marker Ki-67. Additionally we examined to what extent expression of ER? and the other proteins affects survival of ovarian cancer patients. METHODS:We established a tissue microarray from 171 ovarian cancer patients and performed immunohistochemical analyses of the mentioned proteins. RESULTS:Nuclear ER? was detected in 47.31% of the ovarian cancer tissues and cytoplasmic expression of this receptor was observed in 23.08%. Nuclear expression of ER? was significantly decreased in the G3 subgroup compared to better differentiated cancers (p 

SUBMITTER: Schuler-Toprak S 

PROVIDER: S-EPMC6192185 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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