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Self-Reporting Chemically Induced Protein Proximity System Based on a Malachite Green Derivative and the L5** Fluorogen Activating Protein.


ABSTRACT: A unique chemically induced proximity method is engineered based on mutant antibody VL domain using a fluorogenic malachite green derivative as the inducer, which gives fluorescent signals upon VL domain dimerization while simultaneously inducing downstream biological effects.

SUBMITTER: Zeng G 

PROVIDER: S-EPMC6233874 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

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