Unknown

Dataset Information

0

Dissecting Pathogenetic Mechanisms and Therapeutic Strategies in Drosophila Models of Myotonic Dystrophy Type 1.


ABSTRACT: Myotonic dystrophy type 1 (DM1), the most common cause of adult-onset muscular dystrophy, is autosomal dominant, multisystemic disease with characteristic symptoms including myotonia, heart defects, cataracts and testicular atrophy. DM1 disease is being successfully modelled in Drosophila allowing to identify and validate new pathogenic mechanisms and potential therapeutic strategies. Here we provide an overview of insights gained from fruit fly DM1 models, either: (i) fundamental with particular focus on newly identified gene deregulations and their link with DM1 symptoms; or (ii) applied via genetic modifiers and drug screens to identify promising therapeutic targets.

SUBMITTER: Souidi A 

PROVIDER: S-EPMC6321436 | BioStudies | 2018-01-01

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC5974047 | BioStudies
2013-01-01 | S-EPMC4006279 | BioStudies
2018-01-01 | S-EPMC6218431 | BioStudies
2017-01-01 | S-EPMC5413526 | BioStudies
2004-01-01 | S-EPMC1181975 | BioStudies
2016-01-01 | S-EPMC4979973 | BioStudies
2021-01-01 | S-EPMC7918590 | BioStudies
2017-01-01 | S-EPMC5272183 | BioStudies
2020-01-01 | S-EPMC7452101 | BioStudies
1000-01-01 | S-EPMC3718203 | BioStudies