Unknown

Dataset Information

0

Biodegradable Micelles for NIR/GSH-Triggered Chemophototherapy of Cancer.


ABSTRACT: The chemotherapy of stimuli-responsive drug delivery systems (SDDSs) is a promising method to enhance cancer treatment effects. However, the low efficiency of chemotherapy drugs and poor degradation partly limit the application of SDDSs. Herein, we report doxorubicin (DOX)-loading mixed micelles for biotin-targeting drug delivery and enhanced photothermal/photodynamic therapy (PTT/PDT). Glutathione (GSH)-responsive mixed micelles were prepared by a dialysis method, proportionally mixing polycaprolactone-disulfide bond-biodegradable photoluminescent polymer (PCL-SS-BPLP) and biotin-polyethylene glycol-cypate (biotin-PEG-cypate). Chemically linking cypate into the mixed micelles greatly improved cypate solubility and PTT/PDT effect. The micelles also exhibited good monodispersity and stability in cell medium (~119.7 nm), low critical micelles concentration, good biodegradation, and photodecomposition. The high concentration of GSH in cancer cells and near-infrared light (NIR)-mediated cypate decomposition were able to achieve DOX centralized release. Meanwhile, the DOX-based chemotherapy combined with cypate-based NIR-triggered hyperthermia and reactive oxygen species could synergistically induce HepG2 cell death and apoptosis. The in vivo experiments confirmed that the micelles generated hyperthermia and achieved a desirable therapeutic effect. Therefore, the designed biodegradable micelles are promising safe nanovehicles for antitumor drug delivery and chemo/PTT/PDT combination therapy.

SUBMITTER: Zhang C 

PROVIDER: S-EPMC6359036 | BioStudies | 2019-01-01T00:00:00Z

REPOSITORIES: biostudies

Similar Datasets

1000-01-01 | S-EPMC5118601 | BioStudies
2016-01-01 | S-EPMC5347683 | BioStudies
2019-01-01 | S-EPMC6587350 | BioStudies
2019-01-01 | S-EPMC6735506 | BioStudies
2017-01-01 | S-EPMC5915677 | BioStudies
1000-01-01 | S-EPMC6276087 | BioStudies
2017-01-01 | S-EPMC5630134 | BioStudies
2014-01-01 | S-EPMC4568826 | BioStudies
2018-01-01 | S-EPMC6096383 | BioStudies
2019-01-01 | S-EPMC6691384 | BioStudies