Unknown

Dataset Information

0

Ruthenium versus platinum: interactions of anticancer metallodrugs with duplex oligonucleotides characterised by electrospray ionisation mass spectrometry.


ABSTRACT: The binding of the ruthenium-based anticancer drug candidates KP1019, NAMI-A and RAPTA-T towards different double-stranded oligonucleotides was probed by electrospray ionisation mass spectrometry and compared with that of the widely used platinum-based chemotherapeutics cisplatin, carboplatin and oxaliplatin. It was found that the extent of adduct formation decreased in the following order: cisplatin > oxaliplatin > NAMI-A > RAPTA-T > carboplatin > KP1019. In addition to the characterisation of the adducts formed with the DNA models, the binding sites of the metallodrugs on the oligonucleotides were elucidated employing top-down tandem mass spectrometry and were found to be similar for all the metallodrugs studied, irrespective of the sequence of the oligonucleotide. A strong preference for guanine residues was established.

SUBMITTER: Groessl M 

PROVIDER: S-EPMC6485486 | BioStudies | 2010-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7349411 | BioStudies
2020-01-01 | S-EPMC7555145 | BioStudies
2011-01-01 | S-EPMC4361230 | BioStudies
2014-01-01 | S-EPMC4154694 | BioStudies
2017-01-01 | S-EPMC5520548 | BioStudies
2019-01-01 | S-EPMC6704442 | BioStudies
2014-01-01 | S-EPMC4153432 | BioStudies
2015-01-01 | S-EPMC5647740 | BioStudies
2013-01-01 | S-EPMC3817081 | BioStudies
2015-01-01 | S-EPMC5606682 | BioStudies