Unknown

Dataset Information

0

Progressive disorganization of paranodal junctions and compact myelin due to loss of DCC expression by oligodendrocytes.


ABSTRACT: Paranodal axoglial junctions are critical for maintaining the segregation of axonal domains along myelinated axons; however, the proteins required to organize and maintain this structure are not fully understood. Netrin-1 and its receptor Deleted in Colorectal Cancer (DCC) are proteins enriched at paranodes that are expressed by neurons and oligodendrocytes. To identify the specific function of DCC expressed by oligodendrocytes in vivo, we selectively eliminated DCC from mature myelinating oligodendrocytes using an inducible cre regulated by the proteolipid protein promoter. We demonstrate that DCC deletion results in progressive disruption of the organization of axonal domains, myelin ultrastructure, and myelin protein composition. Conditional DCC knock-out mice develop balance and coordination deficits and exhibit decreased conduction velocity. We conclude that DCC expression by oligodendrocytes is required for the maintenance and stability of myelin in vivo, which is essential for proper signal conduction in the CNS.

SUBMITTER: Bull SJ 

PROVIDER: S-EPMC6608320 | BioStudies | 2014-01-01

SECONDARY ACCESSION(S): RRID:AB_1640746

REPOSITORIES: biostudies

Similar Datasets

2011-01-01 | S-EPMC3121702 | BioStudies
2015-01-01 | S-EPMC4339777 | BioStudies
2014-01-01 | S-EPMC4260775 | BioStudies
2000-01-01 | S-EPMC2175192 | BioStudies
1000-01-01 | S-EPMC5272873 | BioStudies
2019-01-01 | S-EPMC6719437 | BioStudies
2018-01-01 | S-EPMC5944142 | BioStudies
2009-01-01 | S-EPMC2725320 | BioStudies
2019-01-01 | S-EPMC6546478 | BioStudies
2006-01-01 | S-EPMC4444368 | BioStudies