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The association of 6 variants of 8q24 and the risk of glioma: A meta-analysis.


ABSTRACT: With the advances in sequencing technologies and genome-wide association studies (GWAS), several inherited variants that increase glioma risk have been identified. Ten studies including 8818 cases and 17,551 controls were collected to conduct a meta-analysis to evaluate the associations between 6 variants in 8q24 and glioma risk. Of the 6 variants located in 8q24, 2 have strong significant associations with the risk of glioma, including rs4295627 (P?=?.003, odds ratio [OR]?=?1.21), rs55705857 (P?=?2.31?×?10, OR?=?3.54). In particular, both homozygous GG (P?=?1.91?×?10, OR1?=?2.01) and heterozygous GT (P?=?7.75?×?10, OR2?=?1.35) genotypes of rs4295627 were associated with glioma risk. Further studies are needed to explore the role of the 8q24 variants involved in the etiology of glioma.

PROVIDER: S-EPMC6635291 | BioStudies |

REPOSITORIES: biostudies

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