Dataset Information


GABA neurons of the VTA drive conditioned place aversion.

ABSTRACT: Salient but aversive stimuli inhibit the majority of dopamine (DA) neurons in the ventral tegmental area (VTA) and cause conditioned place aversion (CPA). The cellular mechanism underlying DA neuron inhibition has not been investigated and the causal link to behavior remains elusive. Here, we show that GABA neurons of the VTA inhibit DA neurons through neurotransmission at GABA(A) receptors. We also observe that GABA neurons increase their firing in response to a footshock and provide evidence that driving GABA neurons with optogenetic effectors is sufficient to affect behavior. Taken together, our data demonstrate that synaptic inhibition of DA neurons drives place aversion.


PROVIDER: S-EPMC6690362 | BioStudies | 2012-01-01

REPOSITORIES: biostudies

Similar Datasets

2019-01-01 | S-EPMC6925992 | BioStudies
2016-01-01 | S-EPMC4846550 | BioStudies
2012-01-01 | S-EPMC3314244 | BioStudies
1000-01-01 | S-EPMC3717537 | BioStudies
2015-01-01 | S-EPMC4522312 | BioStudies
2013-01-01 | S-EPMC3828533 | BioStudies
2019-01-01 | S-EPMC6543524 | BioStudies
2018-01-01 | S-EPMC5773387 | BioStudies
2019-01-01 | S-EPMC6565376 | BioStudies
2020-01-01 | S-EPMC7556367 | BioStudies