Unknown

Dataset Information

0

Structural Insights on Retroviral DNA Integration: Learning from Foamy Viruses.


ABSTRACT: Foamy viruses (FV) are retroviruses belonging to the Spumaretrovirinae subfamily. They are non-pathogenic viruses endemic in several mammalian hosts like non-human primates, felines, bovines, and equines. Retroviral DNA integration is a mandatory step and constitutes a prime target for antiretroviral therapy. This activity, conserved among retroviruses and long terminal repeat (LTR) retrotransposons, involves a viral nucleoprotein complex called intasome. In the last decade, a plethora of structural insights on retroviral DNA integration arose from the study of FV. Here, we review the biochemistry and the structural features of the FV integration apparatus and will also discuss the mechanism of action of strand transfer inhibitors.

SUBMITTER: Lee GE 

PROVIDER: S-EPMC6784120 | BioStudies | 2019-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7305164 | BioStudies
2017-01-01 | S-EPMC5660667 | BioStudies
2017-01-01 | S-EPMC5712078 | BioStudies
1000-01-01 | S-EPMC4848512 | BioStudies
2016-01-01 | S-EPMC4908968 | BioStudies
2017-01-01 | S-EPMC5508583 | BioStudies
2006-01-01 | S-EPMC1360565 | BioStudies
1000-01-01 | S-EPMC4435593 | BioStudies
2016-01-01 | S-EPMC5102385 | BioStudies
1000-01-01 | S-EPMC2936642 | BioStudies