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The Roles of FoxO Transcription Factors in Regulation of Bone Cells Function.


ABSTRACT: Forkhead box class O family member proteins (FoxOs) are evolutionarily conserved transcription factors for their highly conserved DNA-binding domain. In mammalian species, all the four FoxO members, FoxO1, FoxO3, FoxO4, and FoxO6, are expressed in different organs. In bone, the first three members are extensively expressed and more studied. Bone development, remodeling, and homeostasis are all regulated by multiple cell lineages, including osteoprogenitor cells, chondrocytes, osteoblasts, osteocytes, osteoclast progenitors, osteoclasts, and the intercellular signaling among these bone cells. The disordered FoxOs function in these bone cells contribute to osteoarthritis, osteoporosis, or other bone diseases. Here, we review the current literature of FoxOs for their roles in bone cells, focusing on helping researchers to develop new therapeutic approaches and prevent or treat the related bone diseases.

SUBMITTER: Ma X 

PROVIDER: S-EPMC7037875 | BioStudies | 2020-01-01

SECONDARY ACCESSION(S): 10.11138/ccmbm/2017.14.1.209

REPOSITORIES: biostudies

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Oxidative stress in bone remodeling: role of antioxidants.

Domazetovic Vladana V   Marcucci Gemma G   Iantomasi Teresa T   Brandi Maria Luisa ML   Vincenzini Maria Teresa MT  

Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases 20170501 2


ROS are highly reactive molecules which consist of a number of diverse chemical species, including radical and non-radical oxygen species. Oxidative stress occurs as a result of an overproduction of ROS not balanced by an adequate level of antioxidants. The natural antioxidants are: thiol compounds among which GSH is the most representative, and non-thiol compounds such as polyphenols, vitamins and also various enzymes. Many diseases have been linked to oxidative stress including bone diseases a  ...[more]

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