Unknown

Dataset Information

0

A Clinico-Genotypic Prognostic Index for De Novo Composite Diffuse Large B-Cell Lymphoma Arising from Follicular Lymphoma in Asian patients treated in the Rituximab Era.


ABSTRACT: Composite follicular lymphoma with diffuse large B-cell lymphoma (FL/DLBCL) is uncommonly found on lymph node biopsy and represents a rare haematological malignancy. We aim to examine clinico-pathological features of patients with FL/DLBCL and investigate predictors of survival outcome. We included in our retrospective study patients with histologically-proven FL/DLBCL at diagnosis (n?=?106) and who were subsequently treated with rituximab-based chemoimmunotherapy from 2002-2017 at the National Cancer Centre. The cohort consisted of 34 women and 72 men with a median age of 59 years (range, 24-82). In a multivariate model inclusive of known clinico-pathological parameters at diagnosis, advanced stage (p?=?0.0136), presence of MYC and/or BCL6 rearrangement (p?=?0.0376) and presence of B symptoms (p?=?0.0405) were independently prognostic for worse overall survival (OS). The only remaining independent prognostic variables for worse OS after including first-line treatment data in the model were use of chemotherapy regimens other than R-CHOP (p?=?0.0360) and lack of complete response to chemotherapy (p?

SUBMITTER: Lim RMH 

PROVIDER: S-EPMC7062756 | BioStudies | 2020-01-01

SECONDARY ACCESSION(S): 10.18632/oncotarget.24701

REPOSITORIES: biostudies

Similar Datasets

2011-01-01 | S-EPMC7394278 | BioStudies
1000-01-01 | S-EPMC4433526 | BioStudies
2017-01-01 | S-EPMC5680759 | BioStudies
2016-01-01 | S-EPMC5363560 | BioStudies
2019-01-01 | S-EPMC6556027 | BioStudies
2011-01-01 | S-EPMC3217596 | BioStudies
2020-01-01 | S-EPMC7585299 | BioStudies
2018-01-01 | S-EPMC5894967 | BioStudies
2019-01-01 | S-EPMC6443577 | BioStudies
2017-01-01 | S-EPMC5648852 | BioStudies