Dataset Information


Detection of COVID-19: A review of the current literature and future perspectives.

ABSTRACT: The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the coronavirus disease 2019 (COVID-19) worldwide pandemic. This unprecedented situation has garnered worldwide attention. An effective strategy for controlling the COVID-19 pandemic is to develop highly accurate methods for the rapid identification and isolation of SARS-CoV-2 infected patients. Many companies and institutes are therefore striving to develop effective methods for the rapid detection of SARS-CoV-2 ribonucleic acid (RNA), antibodies, antigens, and the virus. In this review, we summarize the structure of the SARS-CoV-2 virus, its genome and gene expression characteristics, and the current progression of SARS-CoV-2 RNA, antibodies, antigens, and virus detection. Further, we discuss the reasons for the observed false-negative and false-positive RNA and antibody detection results in practical clinical applications. Finally, we provide a review of the biosensors which hold promising potential for point-of-care detection of COVID-19 patients. This review thereby provides general guidelines for both scientists in the biosensing research community and for those in the biosensor industry to develop a highly sensitive and accurate point-of-care COVID-19 detection system, which would be of enormous benefit for controlling the current COVID-19 pandemic.


PROVIDER: S-EPMC7371595 | BioStudies | 2020-01-01

REPOSITORIES: biostudies

Similar Datasets

2020-01-01 | S-EPMC7665365 | BioStudies
2020-01-01 | S-EPMC7359073 | BioStudies
2020-01-01 | S-EPMC7428436 | BioStudies
2020-01-01 | S-EPMC7360901 | BioStudies
2020-01-01 | S-EPMC7703470 | BioStudies
2020-01-01 | S-EPMC7409380 | BioStudies
2020-01-01 | S-EPMC7194987 | BioStudies
2020-01-01 | S-EPMC7601663 | BioStudies
2020-01-01 | S-EPMC7695440 | BioStudies
2020-01-01 | S-EPMC7293477 | BioStudies