Dataset Information


Vitamin E acetate as linactant in the pathophysiology of EVALI.

ABSTRACT: The recent identification of Vitamin E acetate as one of the causal agents for the e-cigarette, or vaping, product use associated lung injury (EVALI) is a major milestone. In membrane biophysics, Vitamin E is a linactant and a potent modulator of lateral phase separation that effectively reduces the line tension at the two-dimensional phase boundaries and thereby exponentially increases the surface viscosity of the pulmonary surfactant. Disrupted dynamics of respiratory compression-expansion cycling may result in an extensive hypoxemia, leading to an acute respiratory distress entailing the formation of intraalveolar lipid-laden macrophages. Supplementation of pulmonary surfactants which retain moderate level of cholesterol and controlled hypothermia for patients are recommended when the hypothesis that the line-active property of the vitamin derivative drives the pathogenesis of EVALI holds.

PROVIDER: S-EPMC7422838 | BioStudies |

REPOSITORIES: biostudies

Similar Datasets

| S-EPMC7470376 | BioStudies
| S-EPMC7032996 | BioStudies
| S-EPMC7313101 | BioStudies
| S-EPMC7095090 | BioStudies
| S-EPMC7394920 | BioStudies
| S-EPMC7348611 | BioStudies
| S-EPMC7013172 | BioStudies
| S-EPMC8599147 | BioStudies
| S-EPMC7151740 | BioStudies
| S-EPMC7790140 | BioStudies