Unknown

Dataset Information

0

Argonaute Proteins Take Center Stage in Cancers.


ABSTRACT: Argonaute proteins (AGOs) play crucial roles in RNA-induced silencing complex (RISC) formation and activity. AGOs loaded with small RNA molecules (miRNA or siRNA) either catalyze endoribonucleolytic cleavage of target RNAs or recruit factors responsible for translational silencing and target destabilization. miRNAs are well characterized and broadly studied in tumorigenesis; nevertheless, the functions of the AGOs in cancers have lagged behind. Here, we discuss the current state of knowledge on the role of AGOs in tumorigenesis, highlighting canonical and non-canonical functions of AGOs in cancer cells, as well as the biomarker potential of AGO expression in different of tumor types. Furthermore, we point to the possible application of the AGOs in development of novel therapeutic approaches.

SUBMITTER: Nowak I 

PROVIDER: S-EPMC7918559 | BioStudies | 2021-01-01

SECONDARY ACCESSION(S): rs595961

REPOSITORIES: biostudies

Similar Datasets

2012-07-12 | E-GEOD-39146 | BioStudies
2012-01-01 | S-EPMC3604743 | BioStudies
2014-01-01 | S-EPMC4009607 | BioStudies
1000-01-01 | S-EPMC5098119 | BioStudies
1000-01-01 | S-EPMC4627090 | BioStudies
2012-07-12 | E-GEOD-39146 | ArrayExpress
2010-01-01 | S-EPMC2835997 | BioStudies
2011-01-01 | S-EPMC3107324 | BioStudies
2014-02-19 | E-GEOD-55122 | ArrayExpress
2016-01-01 | S-EPMC5084781 | BioStudies