Genomics

Dataset Information

3

GBM


ABSTRACT: Organisation EGAO00000000361

ORGANISM(S): Homo sapiens  

PROVIDER: EGAO00000000361 | EGA |

REPOSITORIES: EGA

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Publications


Glioblastoma (GBM) is a prototypical heterogeneous brain tumor refractory to conventional therapy. A small residual population of cells escapes surgery and chemoradiation, resulting in a typically fatal tumor recurrence ∼ 7 mo after diagnosis. Understanding the molecular architecture of this residual population is critical for the development of successful therapies. We used whole-genome sequencing and whole-exome sequencing of multiple sectors from primary and paired recurrent GBM tumors to rec  ...[more]

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