Genomics

Dataset Information

0

UAMS


ABSTRACT: Organisation EGAO00000000773

ORGANISM(S): Homo sapiens  

PROVIDER: EGAO00000000773 | EGA |

REPOSITORIES: EGA

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Publications

Clonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients.

Jones John R JR   Weinhold Niels N   Ashby Cody C   Walker Brian A BA   Wardell Chris C   Pawlyn Charlotte C   Rasche Leo L   Melchor Lorenzo L   Cairns David A DA   Gregory Walter M WM   Johnson David D   Begum Dil B DB   Ellis Sidra S   Sherborne Amy L AL   Cook Gordon G   Kaiser Martin F MF   Drayson Mark T MT   Owen Roger G RG   Jackson Graham H GH   Davies Faith E FE   Greaves Mel M   Morgan Gareth J GJ  

Haematologica 20190207 7


The emergence of treatment resistant sub-clones is a key feature of relapse in multiple myeloma. Therapeutic attempts to extend remission and prevent relapse include maximizing response and the use of maintenance therapy. We used whole exome sequencing to study the genetics of paired samples taken at presentation and at relapse from 56 newly diagnosed patients, following induction therapy, randomized to receive either lenalidomide maintenance or observation as part of the Myeloma XI trial. Patie  ...[more]

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