Dataset Information


Expression, MeDIP and ChIP-on-chip data from normal Prostate epithelial cells (PrEC) and the LNCaP cancer cell line

ABSTRACT: This SuperSeries is composed of the SubSeries listed below. Overall design: Refer to individual Series

INSTRUMENT(S): [Hs_PromPR] Affymetrix Human Promoter 1.0R Array

SUBMITTER: Aaron Statham  

PROVIDER: GSE19726 | GEO | 2010-01-04



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Consolidation of the cancer genome into domains of repressive chromatin by long-range epigenetic silencing (LRES) reduces transcriptional plasticity.

Coolen Marcel W MW   Stirzaker Clare C   Song Jenny Z JZ   Statham Aaron L AL   Kassir Zena Z   Moreno Carlos S CS   Young Andrew N AN   Varma Vijay V   Speed Terence P TP   Cowley Mark M   Lacaze Paul P   Kaplan Warren W   Robinson Mark D MD   Clark Susan J SJ  

Nature cell biology 20100221 3

Silencing of individual genes can occur by genetic and epigenetic processes during carcinogenesis, but the underlying mechanisms remain unclear. By creating an integrated prostate cancer epigenome map using tiling arrays, we show that contiguous regions of gene suppression commonly occur through long-range epigenetic silencing (LRES). We identified 47 LRES regions in prostate cancer, typically spanning about 2 Mb and harbouring approximately 12 genes, with a prevalence of tumour suppressor and m  ...[more]

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