Ontology highlight
ABSTRACT:
SUBMITTER: Sun,Qiang
REPOSITORIES: NODE
Liu Zhen Z Cai Yijun Y Wang Yan Y Nie Yanhong Y Zhang Chenchen C Xu Yuting Y Zhang Xiaotong X Lu Yong Y Wang Zhanyang Z Poo Muming M Sun Qiang Q
Cell 20180201 4
Generation of genetically uniform non-human primates may help to establish animal models for primate biology and biomedical research. In this study, we have successfully cloned cynomolgus monkeys (Macaca fascicularis) by somatic cell nuclear transfer (SCNT). We found that injection of H3K9me3 demethylase Kdm4d mRNA and treatment with histone deacetylase inhibitor trichostatin A at one-cell stage following SCNT greatly improved blastocyst development and pregnancy rate of transplanted SCNT embryo ...[more]