Dataset Information


Homo sapiens

ABSTRACT: Donor lung tissues: Control vs. Primary graft dysfunction (PGD)

ORGANISM(S): Homo sapiens  



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Impact of human donor lung gene expression profiles on survival after lung transplantation: a case-control study.

Anraku M M   Cameron M J MJ   Waddell T K TK   Liu M M   Arenovich T T   Sato M M   Cypel M M   Pierre A F AF   de Perrot M M   Kelvin D J DJ   Keshavjee S S  

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 20080822 10

Primary graft dysfunction (PGD) continues to be a major cause of early death after lung transplantation. Moreover, there remains a lack of accurate pretransplant molecular markers for predicting PGD. To identify distinctive donor lung gene expression signatures associated with PGD, we profiled human donor lungs using microarray technology prior to implantation. The genomic profiles of 10 donor lung samples from patients who subsequently developed clinically defined severe PGD were compared with  ...[more]

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