Dataset Information


Bos taurus

ABSTRACT: Bovine Peyer's Patch Infected with Mycobacterium avium ssp. paratuberculosis and Mycobacterium avium ssp. avium

ORGANISM(S): Bos taurus  



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Systems biology analysis of gene expression during in vivo Mycobacterium avium paratuberculosis enteric colonization reveals role for immune tolerance.

Khare Sangeeta S   Lawhon Sara D SD   Drake Kenneth L KL   Nunes Jairo E S JE   Figueiredo Josely F JF   Rossetti Carlos A CA   Gull Tamara T   Everts Robin E RE   Lewin Harris A HA   Galindo Cristi L CL   Garner Harold R HR   Adams Leslie Garry LG  

PloS one 20120817 8

Survival and persistence of Mycobacterium avium subsp. paratuberculosis (MAP) in the intestinal mucosa is associated with host immune tolerance. However, the initial events during MAP interaction with its host that lead to pathogen survival, granulomatous inflammation, and clinical disease progression are poorly defined. We hypothesize that immune tolerance is initiated upon initial contact of MAP with the intestinal Peyer's patch. To test our hypothesis, ligated ileal loops in neonatal calves w  ...[more]

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