Dataset Information


Homo sapiens

ABSTRACT: Comparison of stable human Treg and Th clones by transcriptional profiling - experiment I

ORGANISM(S): Homo sapiens  



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Comparison of stable human Treg and Th clones by transcriptional profiling.

Stockis Julie J   Fink Wolfram W   François Violaine V   Connerotte Thierry T   de Smet Charles C   Knoops Laurent L   van der Bruggen Pierre P   Boon Thierry T   Coulie Pierre G PG   Lucas Sophie S  

European journal of immunology 20090301 3

From cancerous and non-cancerous patients, we derived stable clones of CD4(+) Treg, defined as clones that expressed high CD25 at rest, were anergic in vitro, and suppressed the proliferation of co-cultured CD4(+) cells. A conserved region of FOXP3 intron 1 was demethylated in all Treg clones, whereas it was methylated in non-regulatory Th and CTL clones. In our panel of human clones, this stable epigenetic mark correlated better with suppressive activity than did FOXP3 mRNA or protein expressio  ...[more]

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