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ABSTRACT: Response of bronchial epithelial cells to low doses of cigarette smoke condensate



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Chronic exposure to cigarette smoke condensate in vitro induces epithelial to mesenchymal transition-like changes in human bronchial epithelial cells, BEAS-2B.

Veljkovic Emilija E   Jiricny Josef J   Menigatti Mirco M   Rehrauer Hubert H   Han Wanjiang W  

Toxicology in vitro : an international journal published in association with BIBRA 20101121 2

Cigarette smoke causes lung tumorigenesis; however, the mechanisms underlying transformation are unknown. We investigated if tobacco compounds induce DNA promoter hypermethylation in BEAS-2B cells treated with low doses of cigarette smoke condensate (CSC) for one month. Transcriptional profiles and anchorage-independent growth were explored using Affymetrix microarray and soft agar assay, respectively. To investigate if tobacco compounds induce hypermethylation, CSC/dimethyl sulfoxide (DMSO)-tre  ...[more]

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