Genomics,Multiomics

Dataset Information

0

Homo sapiens


ABSTRACT: mRNAs associated with human PUM1 protein

OTHER RELATED OMICS DATASETS IN: E-GEOD-12357

PROVIDER: PRJNA114189 | ENA |

REPOSITORIES: ENA

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Publications

Comparative analysis of mRNA targets for human PUF-family proteins suggests extensive interaction with the miRNA regulatory system.

Galgano Alessia A   Forrer Michael M   Jaskiewicz Lukasz L   Kanitz Alexander A   Zavolan Mihaela M   Gerber André P AP  

PloS one 20080908 9


Genome-wide identification of mRNAs regulated by RNA-binding proteins is crucial to uncover post-transcriptional gene regulatory systems. The conserved PUF family RNA-binding proteins repress gene expression post-transcriptionally by binding to sequence elements in 3'-UTRs of mRNAs. Despite their well-studied implications for development and neurogenesis in metazoa, the mammalian PUF family members are only poorly characterized and mRNA targets are largely unknown. We have systematically identif  ...[more]

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