Genomics

Dataset Information

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Saccharomyces cerevisiae


ABSTRACT: RNA Synthesis Precision is Regulated by Preinitiation Complex Turnover

ORGANISM(S): Saccharomyces cerevisiae  

PROVIDER: PRJNA117963 | ENA |

REPOSITORIES: ENA

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RNA synthesis precision is regulated by preinitiation complex turnover.

Poorey Kunal K   Sprouse Rebekka O RO   Wells Melissa N MN   Viswanathan Ramya R   Bekiranov Stefan S   Auble David T DT  

Genome research 20100920 12


TATA-binding protein (TBP) nucleates the assembly of the transcription preinitiation complex (PIC), and although TBP can bind promoters with high stability in vitro, recent results establish that virtually the entire TBP population is highly dynamic in yeast nuclei in vivo. This dynamic behavior is surprising in light of models that posit that a stable TBP-containing scaffold facilitates transcription reinitiation at active promoters. The dynamic behavior of TBP is a consequence of the enzymatic  ...[more]

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