Dataset Information


Mus musculus

ABSTRACT: Transcriptome of mouse primary muscle cultures upon dystrophin knockdown by RNAi.

ORGANISM(S): Mus musculus  



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Transcriptomic analysis of dystrophin RNAi knockdown reveals a central role for dystrophin in muscle differentiation and contractile apparatus organization.

Ghahramani Seno Mohammad M MM   Trollet Capucine C   Athanasopoulos Takis T   Graham Ian R IR   Hu Pingzhao P   Dickson George G  

BMC genomics 20100601

BACKGROUND: Duchenne muscular dystrophy (DMD) is a fatal muscle wasting disorder caused by mutations in the dystrophin gene. DMD has a complex and as yet incompletely defined molecular pathophysiology hindering development of effective ameliorative approaches. Transcriptomic studies so far conducted on dystrophic cells and tissues suffer from non-specific changes and background noise due to heterogeneous comparisons and secondary pathologies. A study design in which a perfectly matched control c  ...[more]

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