Dataset Information


Homo sapiens

ABSTRACT: Gene expression profiling of human unstimulated regulatory T cells (Tregs) and naïve CD4+ T cells

ORGANISM(S): Homo sapiens  



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Requirements for growth and IL-10 expression of highly purified human T regulatory cells.

Bonacci Benedetta B   Edwards Brandon B   Jia Shuang S   Williams Calvin B CB   Hessner Martin J MJ   Gauld Stephen B SB   Verbsky James W JW  

Journal of clinical immunology 20120505 5

Human regulatory T cells (T(R)) cells have potential for the treatment of a variety of immune mediated diseases but the anergic phenotype of these cells makes them difficult to expand in vitro. We have examined the requirements for growth and cytokine expression from highly purified human T(R) cells, and correlated these findings with the signal transduction events of these cells. We demonstrate that these cells do not proliferate or secrete IL-10 even in the presence of high doses of IL-2. Stim  ...[more]

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