Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: Gene expression profiling of human unstimulated regulatory T cells (Tregs) and naïve CD4+ T cells

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA129001 | ENA |

REPOSITORIES: ENA

altmetric image

Publications

Requirements for growth and IL-10 expression of highly purified human T regulatory cells.

Bonacci Benedetta B   Edwards Brandon B   Jia Shuang S   Williams Calvin B CB   Hessner Martin J MJ   Gauld Stephen B SB   Verbsky James W JW  

Journal of clinical immunology 20120505 5


Human regulatory T cells (T(R)) cells have potential for the treatment of a variety of immune mediated diseases but the anergic phenotype of these cells makes them difficult to expand in vitro. We have examined the requirements for growth and cytokine expression from highly purified human T(R) cells, and correlated these findings with the signal transduction events of these cells. We demonstrate that these cells do not proliferate or secrete IL-10 even in the presence of high doses of IL-2. Stim  ...[more]

Similar Datasets

2017-08-28 | PXD004291 | Pride
2016-01-19 | E-GEOD-76598 | ArrayExpress
2018-05-18 | PXD007744 | Pride
2018-05-18 | PXD007745 | Pride
2018-05-18 | PXD005477 | Pride
2018-10-08 | GSE112593 | GEO
| GSE94396 | GEO
| GSE119372 | GEO
| GSE90600 | GEO
2014-12-11 | E-GEOD-62535 | ArrayExpress