Dataset Information


Homo sapiens

ABSTRACT: CpG islands Methylation Profiling by DMH in Epithelial Ovarian Cancer: Screening Set

ORGANISM(S): Homo sapiens  



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Systematic CpG islands methylation profiling of genes in the wnt pathway in epithelial ovarian cancer identifies biomarkers of progression-free survival.

Dai Wei W   Teodoridis Jens M JM   Zeller Constanze C   Graham Janet J   Hersey Jenny J   Flanagan James M JM   Stronach Euan E   Millan David W DW   Siddiqui Nadeem N   Paul Jim J   Brown Robert R  

Clinical cancer research : an official journal of the American Association for Cancer Research 20110401 12

PURPOSE:Wnt pathways control key biological processes that potentially impact on tumor progression and patient survival. We aimed to evaluate DNA methylation at promoter CpG islands (CGI) of Wnt pathway genes in ovarian tumors at presentation and identify biomarkers of patient progression-free survival (PFS). EXPERIMENTAL DESIGN:Epithelial ovarian tumors (screening study n = 120, validation study n = 61), prospectively collected through a cohort study, were analyzed by differential methylation h  ...[more]

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