Dataset Information


Staphylococcus aureus

ABSTRACT: Inhibitors that block initiation of wall teichoic acid biosynthesis sensitize methicillin-resistant Staphylococcus aureus to beta-lactams

ORGANISM(S): Staphylococcus aureus  



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Synthetic lethal compound combinations reveal a fundamental connection between wall teichoic acid and peptidoglycan biosyntheses in Staphylococcus aureus.

Campbell Jennifer J   Singh Atul K AK   Santa Maria John P JP   Kim Younghoon Y   Brown Stephanie S   Swoboda Jonathan G JG   Mylonakis Eleftherios E   Wilkinson Brian J BJ   Walker Suzanne S  

ACS chemical biology 20101104 1

Methicillin resistance in Staphylococcus aureus depends on the production of mecA, which encodes penicillin-binding protein 2A (PBP2A), an acquired peptidoglycan transpeptidase (TP) with reduced susceptibility to β-lactam antibiotics. PBP2A cross-links nascent peptidoglycan when the native TPs are inhibited by β-lactams. Although mecA expression is essential for β-lactam resistance, it is not sufficient. Here we show that blocking the expression of wall teichoic acids (WTAs) by inhibiting the fi  ...[more]

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