Dataset Information


Homo sapiens

ABSTRACT: A time series study on BMP6 induced osteoblast differentiation of human mesenchymal stem cells (hMSC)

ORGANISM(S): Homo sapiens  



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Time series gene expression profiling and temporal regulatory pathway analysis of BMP6 induced osteoblast differentiation and mineralization.

Luo Weijun W   Friedman Michael S MS   Hankenson Kurt D KD   Woolf Peter J PJ  

BMC systems biology 20110523

BMP6 mediated osteoblast differentiation plays a key role in skeletal development and bone disease. Unfortunately, the signaling pathways regulated by BMP6 are largely uncharacterized due to both a lack of data and the complexity of the response.To better characterize the signaling pathways responsive to BMP6, we conducted a time series microarray study to track BMP6 induced osteoblast differentiation and mineralization. These temporal data were analyzed using a customized gene set analysis appr  ...[more]

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