Dataset Information


Homo sapiens

ABSTRACT: Modulators of Prostate Cancer Cell Proliferation and Viability Identified by Short-Hairpin RNA Library Screening

ORGANISM(S): Homo sapiens  



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Modulators of prostate cancer cell proliferation and viability identified by short-hairpin RNA library screening.

Dahlman Kimberly Brown KB   Parker Joel S JS   Shamu Tambudzai T   Hieronymus Haley H   Chapinski Caren C   Carver Brett B   Chang Kenneth K   Hannon Gregory J GJ   Sawyers Charles L CL  

PloS one 20120411 4

There is significant need to identify novel prostate cancer drug targets because current hormone therapies eventually fail, leading to a drug-resistant and fatal disease termed castration-resistant prostate cancer. To functionally identify genes that, when silenced, decrease prostate cancer cell proliferation or induce cell death in combination with antiandrogens, we employed an RNA interference-based short hairpin RNA barcode screen in LNCaP human prostate cancer cells. We identified and valida  ...[more]

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