Genomics

Dataset Information

235

Relationship between DNMT1-RNA interactions, DNA methylation and gene expression


ABSTRACT: Relationship between DNMT1-RNA interactions, DNA methylation and gene expression

PROVIDER: PRJNA147345 | ENA |

REPOSITORIES: ENA

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Publications


DNA methylation was first described almost a century ago; however, the rules governing its establishment and maintenance remain elusive. Here we present data demonstrating that active transcription regulates levels of genomic methylation. We identify a novel RNA arising from the CEBPA gene locus that is critical in regulating the local DNA methylation profile. This RNA binds to DNMT1 and prevents CEBPA gene locus methylation. Deep sequencing of transcripts associated with DNMT1 combined with gen  ...[more]

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