Dataset Information


Mus musculus

ABSTRACT: Hedgehog signaling in T cell differentiation

ORGANISM(S): Mus musculus  



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The transcriptional activator Gli2 modulates T-cell receptor signalling through attenuation of AP-1 and NFκB activity.

Furmanski Anna L AL   Barbarulo Alessandro A   Solanki Anisha A   Lau Ching-In CI   Sahni Hemant H   Saldana Jose Ignacio JI   D'Acquisto Fulvio F   Crompton Tessa T  

Journal of cell science 20150423 11

Different tissues contain diverse and dynamic cellular niches, providing distinct signals to tissue-resident or migratory infiltrating immune cells. Hedgehog (Hh) proteins are secreted inter-cellular signalling molecules, which are essential during development and are important in cancer, post-natal tissue homeostasis and repair. Hh signalling mediated by the Hh-responsive transcription factor Gli2 also has multiple roles in T-lymphocyte development and differentiation. Here, we investigate the  ...[more]

Publication: 1/2

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