Genomics

Dataset Information

0

Homo sapiens


ABSTRACT: SHARP1 suppresses breast cancer metastasis by promoting degradation of hypoxia-inducible factors

ORGANISM(S): Homo sapiens  

PROVIDER: PRJNA150029 | ENA |

REPOSITORIES: ENA

altmetric image

Publications


The molecular determinants of malignant cell behaviours in breast cancer remain only partially understood. Here we show that SHARP1 (also known as BHLHE41 or DEC2) is a crucial regulator of the invasive and metastatic phenotype in triple-negative breast cancer (TNBC), one of the most aggressive types of breast cancer. SHARP1 is regulated by the p63 metastasis suppressor and inhibits TNBC aggressiveness through inhibition of hypoxia-inducible factor 1α (HIF-1α) and HIF-2α (HIFs). SHARP1 opposes H  ...[more]

Similar Datasets

1000-01-01 | S-EPMC3695680 | BioStudies
2014-01-01 | S-EPMC3946681 | BioStudies
2020-01-01 | S-EPMC7056556 | BioStudies
2013-01-01 | S-EPMC3674184 | BioStudies
2018-01-01 | S-EPMC6033879 | BioStudies
2016-01-01 | S-EPMC5190041 | BioStudies
1000-01-01 | S-EPMC4825722 | BioStudies
1000-01-01 | S-EPMC5596433 | BioStudies
2013-01-01 | S-EPMC3688768 | BioStudies
2020-01-01 | S-EPMC7175249 | BioStudies