Genomics

Dataset Information

0

Mus musculus


ABSTRACT: Genome-wide analysis of gene expression changes in mouse keratinocytes induced by treatment with DAPT

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA150909 | ENA |

REPOSITORIES: ENA

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Publications


The reprogramming of somatic cells to pluripotency using defined transcription factors holds great promise for biomedicine. However, human reprogramming remains inefficient and relies either on the use of the potentially dangerous oncogenes KLF4 and CMYC or the genetic inhibition of the tumor suppressor gene p53. We hypothesized that inhibition of signal transduction pathways that promote differentiation of the target somatic cells during development might relieve the requirement for non-core pl  ...[more]

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