Dataset Information


Mus musculus

ABSTRACT: Gene-expression profiles of PD-L1-affected CD8+ T cells

ORGANISM(S): Mus musculus  



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PD-L1 on tumor cells is induced in ascites and promotes peritoneal dissemination of ovarian cancer through CTL dysfunction.

Abiko Kaoru K   Mandai Masaki M   Hamanishi Junzo J   Yoshioka Yumiko Y   Matsumura Noriomi N   Baba Tsukasa T   Yamaguchi Ken K   Murakami Ryusuke R   Yamamoto Ayaka A   Kharma Budiman B   Kosaka Kenzo K   Konishi Ikuo I  

Clinical cancer research : an official journal of the American Association for Cancer Research 20130122 6

PURPOSE: Ovarian cancer often progresses by disseminating to the peritoneal cavity, but how the tumor cells evade host immunity during this process is poorly understood. Programmed cell death 1 ligand 1 (PD-L1) is known to suppress immune system and to be expressed in cancer cells. The purpose of this study is to elucidate the function of PD-L1 in peritoneal dissemination. EXPERIMENTAL DESIGN: Ovarian cancer cases were studied by microarray and immunohistochemistry. PD-L1 expression in mouse ova  ...[more]

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