Genomics

Dataset Information

118

Mus musculus


ABSTRACT: Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements

ORGANISM(S): Mus musculus  

PROVIDER: PRJNA177636 | ENA |

REPOSITORIES: ENA

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Publications

Pitx1 broadly associates with limb enhancers and is enriched on hindlimb cis-regulatory elements.

Infante Carlos R CR   Park Sungdae S   Mihala Alexandra G AG   Kingsley David M DM   Menke Douglas B DB  

Developmental biology 20121127 1


Extensive functional analyses have demonstrated that the pituitary homeodomain transcription factor Pitx1 plays a critical role in specifying hindlimb morphology in vertebrates. However, much less is known regarding the target genes and cis-regulatory elements through which Pitx1 acts. Earlier studies suggested that the hindlimb transcription factors Tbx4, HoxC10, and HoxC11 might be transcriptional targets of Pitx1, but definitive evidence for direct regulatory interactions has been lacking. Us  ...[more]

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