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ABSTRACT: Epigenome analysis of uterin leiomyoma and myometrium with or without leiomyoma



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Genome-wide DNA methylation analysis reveals a potential mechanism for the pathogenesis and development of uterine leiomyomas.

Maekawa Ryo R   Sato Shun S   Yamagata Yoshiaki Y   Asada Hiromi H   Tamura Isao I   Lee Lifa L   Okada Maki M   Tamura Hiroshi H   Takaki Eiichi E   Nakai Akira A   Sugino Norihiro N  

PloS one 20130620 6

BACKGROUND: The pathogenesis of uterine leiomyomas, the most common benign tumor in women, remains unclear. Since acquired factors such as obesity, hypertension and early menarche place women at greater risk for uterine leiomyomas, uterine leiomyomas may be associated with epigenetic abnormalities that are caused by unfavorable environmental exposures. PRINCIPAL FINDINGS: Profiles of genome-wide DNA methylation and mRNA expression were investigated in leiomyomas and in myometrium with and withou  ...[more]

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